Sumatriptan delivered in an electric patch form applied to the skin was approved by the Federal Drug Administration (FDA) IN 2013 for the acute treatment of migraine.

The iontophoretic sumatriptan patch is anticipated to become available in the U.S. in early or mid-2015.

Deborah E. Tepper, MD Cleveland Clinic Headache Center recently wrote an article in Headache: The Journal of Head and Face Pain about the patch. The following is part of the article…..

About 25 years ago, sumatriptan was the first drug in the medication class of triptans to be approved for the treatment of migraine. Sumatriptan already comes in a tablet, injectable form, nasal spray, and in at least 14 countries, a suppository. The sumatriptan patch is called brand name Zecuity and is made by Teva Pharmaceutical Industries LTD. It is especially suited to those migraineurs who have ongoing nausea accompanying their headaches, those for whom a pill will not work, and those with a need for a non-oral medication to bypass the gut.

The sumatriptan patch consists of a single-use patch that comes in a foil packet. After tabs are pulled to expose a small well of sumatriptan and another well of salt solution, these areas are each rubbed to release the two compounds. The patch is placed on the upper arm or thigh, in an area where there are no tattoos or skin irritation. A tiny battery embedded in the patch is then turned on by pushing a button. A red light comes on, indicating the patch is activated.

The patch is better for people with slow onset migraine, and in those with nausea with their headaches. One common problem with tablet forms of migraine treatment is that they are frequently poorly absorbed because of a phenomena called gastroparesis, in which the gut slows down and does not move normally during a migraine, contributing to nausea and less reliable absorption of oral medications. The patch, as well as injectable, inhalable, suppository, and nasal formulations of migraine medications, are often more suitable for patients who have gastroparesis with their migraines, often suggested by the presence of nausea itself.

Testing of the patch included 800 migraine patients with and without aura who received either an active patch containing sumatriptan or a placebo patch containing no medicine. In this trial, 18% of patients using the patch had complete relief of their headaches by 2 hours, compared with 9% using a placebo nonfunctional patch. After 2 hours, 53% of patients using the patch had a decrease in their headache pain compared to 29% of those with the placebo patch. No nausea was reported after 2 hours in 84% of patients using the active patch compared with 63% using the placebo.
Headache: The Journal of Head and Face Pain October 2014

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