“Before the headache: Infant colic as an early life expression of migraine” published in the journal Neurology was a cross-sectional study performed in general pediatric clinics.

Childhood periodic syndromes are thought to be early-life expressions of the genetic tendency for migraine. The objective of this study was to determine whether maternal migraine is associated with an increased risk of infant colic, because this could indicate that colic is a childhood periodic syndrome.

The researchers found that maternal migraine is associated with increased risk of infant colic. Because migraine has a strong genetic underpinning, this link suggests that colic may be an early-life manifestation of migraine.
Headache: The Journal of Head and Face Pain October 2014

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