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Topiramate in the Prophylactic
Treatment of Cluster Headache
Lainez MJA, Pascual J., et al
Posted: November 2003  
Headache: 2003;43:784-789

Objective:   The role of topiramate in the prophylactic treatment of cluster headache is still unclear. The aim of this study was to evaluate the effectiveness of topiramate in a group of patients with refractory episodic or chronic cluster headache.

Background:   Proof of efficacy of preventive treatment of cluster headache is limited, especially for the chronic form of the disorder. There are very few randomized clinical trials on this condition with topiramate or other new anticonvulsant agents. Recent case reports and series involving topiramate have shown good results.

Conclusions:   Our results confirm that topiramate can be an effective option for the preventive treatment of episodic and chronic cluster headache.