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Migraine Prevention in Children and
Adolescents: Results of an Open Study with a Special
Butterbur Root Extract
Raymond Pothmann, MD; Ulrich Danesch, PhD.
Posted: April 2005
Objective: To explore the role of a
special butterbur root extract for migraine prevention in children
and adolescents with severe migraines.
Background: Two randomized and placebo-controlled
trials with a total of 289 migraine patients have demonstrated
the efficacy and safety of a special butterbur root extract in
the reduction of migraine attacks in adults. We studied whether
butterbur had the potential as an efficient and well-tolerated
migraine preventive in children and adolescents.
Results: 77% of all patients reported a reduction in
the frequency of migraine attacks of at least 50%. Attack frequency
was reduced by 63%. 91% of patients felt substantially or at least
slightly improved after 4 months of treatment. About 90% of each,
doctors and patients, reported well-being or even improved
well-being. Undesired effects included mostly eructation. No
serious adverse events occurred.
Conclusions: The results and low rate of adverse
events in this open prospective migraine prevention study in
children and adolescents are similar to the results of two
multicenter placebo-controlled butterbur studies in adults.
Butterbur root extract shows a potential as an effective and
well-tolerated migraine prophylaxis also for children and