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Topiramate in the Prevention of Migraine Headache:
Results from Two Randomized, Double-Blind,
Placebo-Controlled Studies
Matthew, N., et al
Posted July 2003
Presented at: 45th Annual Scientific Meeting
American Headache Society
June 19-22, 2003; Chicago, Illinois

Objectives:  To assess the efficacy and safety of topiramate in the prevention of migraine headache.

Conclusions:  In these studies, topiramate was associated with significant improvement in migraine at doses of 100 or 200 mg/day in each efficacy measure presented. The onset of efficacy was observed as early as the first month of treatment.