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Topiramate-Responsive Cluster Headache
Posted Nov 2000
Cephalalgia, May 2000

Objective: This study provides additional open-label evidence favoring topiramate efficacy in the treatment of cluster headache (CH). Previously,we reported 10 cluster headache patients who responded to topiramate; thus this report serves as an extension of the original clinical observation.

Conclusion: Topiramate appears to be efficacious in the treatment of cluster headache, rapidly inducing a cluster remission period in 14 of 18 patients given an adequate trial. There were only four treatment failures, two were associated with intolerable drowsiness. Overall, topiramate proved safe, well tolerated, rapidly acting, and highly effective in the treatment of cluster headache.