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Use of a Pine Bark Extract and Antioxidant Vitamin
Combination Product as Therapy for Migraine in
Patients Refractory to Pharmacologic Medication
Sirichai Chayasirisobhon, MD
Posted: September 2006
Objective: To evaluate the potential
benefit of a pine bark extract and antioxidant vitamin combination
product in the treatment of migraine headache.
Background: This was an uncontrolled preliminary
study to investigate the potential of an antioxidant formulation
as therapy for migraine headache.
Methods: Use of a Pine Bark Extract and Antioxidant
Vitamin Combination Product as Therapy for Migraine Twelve patients
with a long-term history of migraine with and without aura who had
failed to respond to multiple treatments with ß-blockers, antidepressants,
anticonvulsants, and 5-hydroxytryptamine receptor agonists were selected
for the study. They were treated with 10 capsules of an antioxidant
formulation of 120 mg. pine bark extract, 60 mg. vitamin C, and 30 IU
vitamin E in each capsule daily for 3 months. Following enrollment
patients completed a disability assessment questionnaire to give a
baseline measure of migraine impact on work, school, domestic, and
social activities over the previous 3 months. Patients were then
treated for 3 months with the antioxidant formulation while continuing
to receive existing pharmacologic medications. A second questionnaire
was given at the conclusion of the treatment period.
Conclusion: These data suggest that the antioxidant
therapy used in this study may be beneficial in the treatment of
migraine possibly reducing headache frequency and severity. Further
clinical investigation into the efficacy of antioxidant as therapy
for chronic migraine is warranted.