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Migraines Linked to Intrapulmonary Right-to-Left Shunt
Thenganatt J, Schneiderman J, Hyland RH, et al.
Posted: May 2006  
Headache 2006;46:439-443

Objective:   To determine if there is an association between migraines and intrapulmonary right-to-left shunt.

Background:   Several studies have described an association between migraines and intracardiac right-to-left shunt.

Methods:  Patients with hereditary hemorrhagic telangiectasia (HHT) were retrospectively recruited from the Toronto Hereditary Hemorrhagic Telangictasia Center Clinical Database. All patients had been prospectively, systematically asked about a history of migraines and systematically screened for pulmonary and cerebral arteriovenous malformations (AVMs). All patients with a definite diagnosis of HHT, assessed during a 2-year period were included. Univariate analyses and logistic regression were performed, for migraine as the dependent variable ad the following independent variables: age, sex, pulmonary AVMs, and cerebral AVMs.

Conclusions:  There is a significant association between intrapulmonary right-to-left shunt and migraine.