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Caffeine as a Risk Factor for Chronic Daily
Headache: A Population-based Study
Scher AI, Stewart WF, Lipton RB.
Posted: January 2006
Objective: To investigate the possible
association of dietary caffeine consumption and medicinal caffeine
use with chronic daily headache (CDH).
Methods: Population-based cases and controls
reported more than 180 headache days per year. Current and past
dietary caffeine consumption and medication use for headaches were
based on detailed self-report. High caffeine exposure was defined
as being in the upper quartile of dietary consumption or using a
caffeine-containing over-the-counter analgesic as the preferred
Results: In comparison with episodic headache
controls, CDH cases were more likely overall to have been high
caffeine consumers before onset of CDH. No association was found
for current caffeine consumption. In secondary analyses,
associations were confined to younger women and those with chronic
episodic headaches without physician consultation and of recent
Conclusion: Dietary and medicinal caffeine
consumption appears to be a modest risk factor for chronic daily
headache onset, regardless of headache type.