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Double-Blind Placebo-Controlled Study of
Animal studies suggest that subcutaneous injection of
botulinum toxin A (BTX-A), performed before the application of a
noxious stimulus, had antinociceptive effect. This pilot study
tested whether intradermal BTX-A has analgesic properties in humans.
Ten adults with symmetrical chronic back or thigh paih, regardless
of cause, gave informed consent and were treated in double-blind
fashion. All subjects received BTX-A in the painful area on one
side, and an equal volume of saline in the contralateral painful
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